Avicenna Veterinary Research

Avicenna Veterinary Research

Evaluating the Impact of Fusariotoxins on Poultry Feed Safety

Document Type : Review Articles

Authors
1 Department of Animal Feed Hygiene, Faculty of Azad University Veterinary Science, Tehran, Iran
2 Institute of Gricultural Education and Extension, Agricultural Research, Education and Extention Organization (AREEO), Tehran, Iran
3 Department of Basic Sciences, Faculty of Veterinary Medicine, Bu-Ali Sina University, Hamedan, Iran
10.22084/avr.2026.32340.1033
Abstract
This study provides new insights into the prevalence and toxicological impacts of Fusariotoxins in poultry feeds, highlighting the urgent need for integrated management strategies to protect poultry health and improve food safety. These toxins negatively affect poultry by inhibiting growth and increasing their susceptibility to diseases. increased research efforts and enhanced agricultural practices are crucial for mitigating toxin levels in poultry feed. One signi cant aspect of poultry management and welfare practices is the prevalence of Fusarium species poultry feed. These species are commonly found and produce mycotoxins that pose signi cant risks to both poultry and human health. Fusarium fungi are well-known contaminants of agricultural commodities, particularly grains and poultry feeds, due to their hazardous mycotoxins, which threaten poultry health and food safety. The contamination of poultry feeds with Fusarium species and their mycotoxins represents a critical issue due to the detrimental effects on poultry health and productivity. Health challenges associated with mycotoxins produced by Fusarium species are of great concern. This survey compiles ndings from various studies regarding the occurrence of Fusarium species in poultry feeds and the associated toxicological effects. The examination of Fusarium species in poultry feeds has garnered attention within the veterinary and agricultural sciences due to concerns about poultry health and food safety. As this survey will illustrate, there is a pressing need for microbiological, biochemical, and agricultural expertise within the veterinary science domain to understand and mitigate the impact of these fungi on poultry feeds.
Keywords

[1] Agun O, Cao A, Pintos C, Santiago R, Mansilla
P, Butron A. Occurrence of F usarium species in
maize kernels grown in northwestern S pain. Plant
Pathology. 2014 Aug;63(4):946-51.
[2] Ahmad R, Yu YH, Hsiao FS, Su CH, Liu HC,
Tobin I, Zhang G, Cheng YH. In uence of heat
stress on poultry growth performance, intestinal
in ammation, and immune function and poten-
tial mitigation by probiotics. Animals. 2022 Sep
5;12(17):2297.
[3] Alders RG, Dumas SE, Rukambile E, Magoke G,
Maulaga W, Jong J, Costa R. Family poultry: M
ultiple roles, systems, challenges, and options for
sustainable contributions to household nutrition
security through a planetary health lens. Mater-
nal child nutrition. 2018 Oct;14: e12668.
[4] Algabr HM, Alwaseai A, Alzumir MA, Hassen
AA, Taresh SA. Occurrences and frequency of
fungi and detection of mycotoxins on poultry ra-
tions in Yemen. Bulletin of the National Research
Centre. 2018 Dec 19;42(1):32.
[5] Antonissen G, Martel A, Pasmans F, Ducatelle
R, Verbrugghe E, Vandenbroucke V, Li S, Haese-
brouck F, Van Immerseel F, Croubels S. The im-
pact of Fusarium mycotoxins on human and ani-
mal host susceptibility to infectious diseases. Tox-
ins. 2014 Jan 28;6(2):430-52.
[6] Awad W, Ghareeb K, Bhm J, Zentek J. The
toxicological impacts of the Fusarium mycotoxin,
deoxynivalenol, in poultry  ocks with special
reference to immunotoxicity. Toxins. 2013 Apr
29;5(5):912-25.
[7] Brodal G, Aamot HU, Almvik M, Hofgaard IS.
Removal of small kernels reduces the content of
Fusarium mycotoxins in oat grain. Toxins. 2020
May 23;12(5):346.
[8] Brown DW, Butchko RA, Baker SE, Proctor RH.
Phylogenomic and functional domain analysis of
polyketide synthases in Fusarium. Fungal Biology.
2012 Feb 1;116(2):318-31.
[9] Bry la M, Pierzgalski A, Zapasnik A, Uwineza
PA, Ksieniewicz-Wozniak E, Modrzewska M,
Waskiewicz A. Recent research on Fusarium my-
cotoxins in maizeA review. Foods. 2022 Nov
1;11(21):3465.
[10] Chang H, Kim W, Park JH, Kim D, Kim CR,
Chung S, Lee C. The occurrence of zearalenone in
South Korean feedstuffs between 2009 and 2016.
Toxins. 2017 Jul 15;9(7):223.
[11] Cheng Y, Xu Q, Chen Y, Su Y, Wen C, Zhou
Y. Modi ed palygorskite improves immunity, an-
tioxidant ability, intestinal morphology, and bar-
rier function in broiler chickens fed naturally con-
taminated diet with permitted feed concentra-
tions of Fusarium mycotoxins. Toxins. 2018 Nov
20;10(11):482.
[12] Cooper KK, Mourkas E, Schiaffino F, Parker
CT, Pinedo Vasquez TN, Garcia Bardales PF,
Pe~nataro Yori P, Paredes Olortegui M, Man-
zanares Villanueva K, Romaina Cachique L, Silva
Delgado H. Sharing of cmeRABC alleles between
C. coli and C. jejuni associated with extensive
drug resistance in Campylobacter isolates from in-
fants and poultry in the Peruvian Amazon. MBio.
2025 Feb 5;16(2):e02054-24.
[13] Danbappa AA, Alhassan KA, Shah MM. Isola-
tion and identi cation of microbial contaminants
associated with commercial poultry feeds. Jour-
nal of Applied and Advanced Research. 2018 Oct
4;3(5):142-7.
[14] Deepthi BV, Gnanaprakash AP, Sreenivasa MY.
Effect of -irradiation on fumonisin producing
Fusarium associated with animal and poultry feed
mixtures. 3 Biotech. 2017 May;7(1):57.
[15] Dolensek T, Svara T, Kni c T, Gombac M, Luzar
B, Jakovac-Strajn B. The in uence of fusarium
mycotoxins on the liver of gilts and their suckling
piglets. Animals. 2021 Aug 28;11(9):2534.
[16] Dorn B, Forrer HR, Jenny E, Wettstein FE,
Bucheli TD, Vogelgsang S. Fusarium species com-
plex and mycotoxins in grain maize from maize
hybrid trials and from growers  elds. Journal of
applied microbiology. 2011 Sep 1;111(3):693-706.
[17] Ekwomadu TI, Akinola SA, Mwanza M. Fusar-
ium mycotoxins, their metabolites (free, emerg-
ing, and masked), food safety concerns, and
health impacts. International Journal of Environ-
mental Research and Public Health. 2021 Nov
9;18(22):11741.
[18] El-Sharkawy H, Abd El-Salam AM, Tahoun A.
Pathology and epidemiology of fungal infections
in layer chicken  ocks. Advanced Gut Microbiome
Research. 2023;2023(1):9956074.
[19] Wamalwa EN, Muoma J, Muyekho FN, Wekesa
C, Ajanga S. Genetic diversity of Fusarium Oxys-
porum races associated with cowpea  elds in
kakamega county. Fungal Genomics Biology.
2018;8:1-7.
[20] Fraeyman S, Croubels S, Devreese M, Ducatelle R,
Rychlik M, Antonissen G. Chronic dietary intake
of enniatin B in broiler chickens has low impact
on intestinal morphometry and hepatic histology,
and shows limited transfer to liver tissue. Toxins.
2018 Jan 18;10(1):45.
[21] Gar{ J. Current review of biodegradation and
detoxi cation strategies for zearalenone contami-
nated food and feed. International Journal of Sec-
ondary Metabolite. 2024;11(1):157-68.
[22] Ghaemmaghami SS, Modirsaneii M, Khosravi AR,
Razzaghi-Abyaneh M. Study on myco ora of poul-
try feed ingredients and  nished feed in Iran. Ira-
nian journal of microbiology. 2016 Feb;8(1):47.
[23] Ghaemmaghami SS, Nowroozii H, Tohidi MM.
Toxigenic fungal contamination for assessment of
poultry feeds: Mashed vs. Pellet. Iranian Journal
of Toxicology. 2018;12(5),5-10.
[24] Ghaemmaghami SS. A glance of feed hygiene
and importance of mycotoxins in poultry feed-
stuffs. World's Poultry Science Journal. 2024 Oct
1;80(4):1009-15.
[25] Abd El Ghany N, Alagmy G, Rasheed N. The
Immunostimulant Effect of Saccharomyces Cere-
visiae and The Impact of Fusarium Solani Infec-
tion on Oreochromis Niloticus. Slovenian Veteri-
nary Research. 2021 Dec 17;58(24-Suppl):45-58.
[26] Gherbawy YA, Altalhi A, Ioan P, ElDawy EG.
Occurrence of Fusarium Species and Determina-
tion of Their Toxins From Poultry Feeds Dur-
ing Storage. International Journal of Microbiol-
ogy. 2024;2024(1):3474308.
[27] Girgis GN, Smith TK. Comparative aspects of
Fusarium mycotoxicoses in poultry fed diets con-
taining naturally contaminated grains. World's
Poultry Science Journal. 2010 Mar;66(1):65-86.
[28] Girish C, Smith T. Impact of feed-borne mycotox-
ins on avian cell-mediated and humoral immune
responses. World Mycotoxin Journal. 2008 May
1;1(2):105-21.
[29] Gkiorsos V, Michailidis G, Anastasiadou M, Gi-
annenas I. Effects of fumonisin and Salmonella in-
fection in the expression of Toll-like receptors in
chicken ovary. Journal of the Hellenic Veterinary
Medical Society. 2022 Nov 9;73(3):4477-84.
[30] Gomez-Osorio LM, Vasiljevic M, Raj J, Chaparro-
Gutierrez JJ, Lopez-Osorio S. Mycotoxins and
coccidiosis in poultryco-occurrence, interaction,
and effects. Frontiers in Veterinary Science. 2024
Aug 1;11:1387856.
[31] Grace D, Knight-Jones TJ, Melaku A, Alders
R, Jemberu WT. The public health importance
and management of infectious poultry diseases in
smallholder systems in Africa. Foods. 2024 Jan
26;13(3):411.
[32] Greco MV, Franchi ML, Rico Golba SL,
Pardo AG, Pose GN. Mycotoxins and myco-
toxigenic fungi in poultry feed for foodpro-
ducing animals. The Scienti c World Journal.
2014;2014(1):968215.
[33] Greeff-Laubscher MR, Beukes I, Marais GJ, Ja-
cobs K. Mycotoxin production by three different
toxigenic fungi genera on formulated abalone feed
and the effect of an aquatic environment on fu-
monisins. Mycology. 2020 Apr 2;11(2):105-17.
[34] Griessler K, Rodrigues I, Handl J, Hofstetter U.
Occurrence of mycotoxins in Southern Europe.
World Mycotoxin Journal. 2010 Aug 1;3(3):301-9.
[35] Hamasalim HJ, Ahmed BM, Mohammed SJ. In-
uence of Storage Condition and Period Time on
Fungal Contamination and Mycotoxin in Rumi-
nant Feed. Jordan Journal of Agricultural Sci-
ences. 2021 Mar 1;17(1):17-25.
[36] Herkert PF, Al-Hatmi AM, de Oliveira Salvador
GL, Muro MD, Pinheiro RL, Nucci M, Queiroz-
Telles F, de Hoog GS, Meis JF. Molecular charac-
terization and antifungal susceptibility of clinical
Fusarium species from Brazil. Frontiers in Micro-
biology. 2019 Apr 10;10:737.
[37] Hof H. The medical relevance of Fusarium spp.
Journal of fungi. 2020 Jul 24;6(3):117.
[38] Hudu AR, Addy F, Mahunu GK, Abubakari AH,
Opoku N. Zearalenone contamination in maize, its
associated producing fungi, control strategies, and
legislation in S ubS aharan Africa. Food Science
Nutrition. 2024 Jul;12(7):4489-512.
[39] Hussein LF, Saadullah AA. DNA Marker Iden-
ti cation of Trichoderma and Fusarium Level
Species. InIOP Conference Series: Earth and En-
vironmental Science 2023 Dec 1 (Vol. 1252, No. 1,
p. 012175). IOP Publishing.
[40] Jaimez J, Fente CA, Franco CM, Cepeda A,
Vazquez BI. A survey of the fungal contamination
and presence of ochratoxin A and zearalenone on
Spanish feed and raw materials. Journal of the Sci-
ence of Food and Agriculture. 2004 Jun;84(8):832-
40.
[41] Jensen T, De Boevre M, Preuke N De Saeger S,
Birr T, Verreet JA, Snnichsen FD. Evaluation of
high-resolution mass spectrometry for the quanti-
tative analysis of mycotoxins in complex feed ma-
trices. Toxins. 2019 Sep 12;11(9):531.
[42] Krnjaja V, Levic J, Stankovic S. Impor-
tance of toxigenic Fusarium species in ani-
mal food. Biotechnology in Animal Husbandry.
2011;27(3):643-57.
[43] Krnjaja V, Petrovic ST, Stankovic S, Lukic M,
Skrbic Z, Mandic V, Bijelic Z. Mycobiota and a a-
toxin B1 in poultry feeds. Biotechnology in Ani-
mal Husbandry. 2019;35(1):61-9.
[44] Krnjaja V, Stanojkovic A, Petrovic T, Mandic V,
Bijelic Z, Radovic C, Delic N. Fungal contamina-
tion of pig farm feeds. Biotechnology in Animal
Husbandry. 2021;37(2):139-47.
[45] Krnjaja V, Stojanovic LJ, Trenkovski S, Bijelic Z,
Tomasevic D. The frequency of pathogenic fungi
genera in poultry feed. J. Food Agric. Environ.
2010 Jul 1;8(34):589-91.
[46] Kulcsar S, Kovesi B, Balogh K, Zandoki E, An-
csin Z, Marta BE, Mezes M. Effects of Fusarium
mycotoxin exposure on lipid peroxidation and glu-
tathione redox system in the liver of laying hens.
Antioxidants. 2021 Aug 20;10(8):1313.
[47] Latham RL, Boyle JT, Barbano A, Loveman WG,
Brown NA. Diverse mycotoxin threats to safe food
and feed cereals. Essays in biochemistry. 2023
Sep;67(5):797-809.
[48] Liu J, Applegate T. Zearalenone (ZEN) in live-
stock and poultry: dose, toxicokinetics, toxicity
and estrogenicity. Toxins. 2020 Jun 7;12(6):377.
[49] Mansur AR, Yu CC, Oh DH. Efficiency of gamma
irradiation to inactivate growth and fumonisin
production of Fusarium moniliforme on corn
grains. Journal of Microbiology and Biotechnol-
ogy. 2014;24(2):209-16.
[50] Meena PR, Yadav P, Hemlata H, Tejavath
KK, Singh AP. Poultryorigin extraintestinal Es-
cherichia coli strains carrying the traits associated
with urinary tract infection, sepsis, meningitis and
avian colibacillosis in India. Journal of Applied
Microbiology. 2021 Jun 1;130(6):2087-101.
[51] Mitterbauer R, Weindorfer H, Safaie N, Krska R,
Lemmens M, Ruckenbauer P, Kuchler K, Adam
G. A sensitive and inexpensive yeast bioassay for
the mycotoxin zearalenone and other compounds
with estrogenic activity. Applied and Environmen-
tal Microbiology. 2003 Feb;69(2):805-11.
[52] Maina NM, MM M, Zanna MY, Lawani MA,
Vinkings EG. Mycological Evaluation and Myco-
toxin Contamination of Swine and Poultry Feed-
Shelf-Life Assessment in Makurdi, Nigeria. Ap-
proaches in Poultry Dairy Veterinary Sciences.
2018: 2(5).
[53] Monge MD, Magnoli CE, Chiacchiera SM. Sur-
vey of Aspergillus and Fusarium species and their
mycotoxins in raw materials and poultry feeds
from Crdoba, Argentina. Mycotoxin Research.
2012 May;28(2):111-22.
[54] Noman SJ. Mycotoxins in Food. Egyptian Aca-
demic Journal of Biological Sciences, G. Microbi-
ology. 2022 Aug 8;14(2):19-28.
[55] Okechukwu NP, Ngozika NC, Ndubueze A, Chris-
tain O. Isolation and identi cation of mycotoxi-
genic organisms in poultry feed from selected lo-
cations in Abia State, Nigeria. Asian Journal of
Research in Animal and Veterinary Sciences. 2019
Jul 24;2(2):139-47.
[56] Nowrozi H, Farhadi A, Kachuei R, Ghaem-
maghami SS. Two important fusarium in
esophageal cancer, fusarium verticillioides and
fusarium proliferatum: myco ora isolation and
molecular characterization in Iranian feed and
corn. Journal of Research in Medical and Dental
Science. 2018;6(6):239.
[57] Omori AM, Ono EY, Hirozawa MT, de Souza
Suguiura IM, Hirooka EY, Pelegrinelli Fungaro
MH, Ono MA. Development of indirect competi-
tive enzyme-linked immunosorbent assay to detect
Fusarium verticillioides in poultry feed samples.
Toxins. 2019 Jan 17;11(1):48.
[58] Onajob{ IB, Adebanjo OL, Samson OJ, Ab{ona
TO, Ogunmoye AO, Makanjuola SO, Adebajo LO.
Microorganisms associated with poultry feeds in
South West, Nigeria. Journal of Poultry Research.
2023 Jun 6;20(1):1-2.
[59] Ostry V, Ovesna J, Skarkova J, Pouchova V,
Ruprich J. A review on comparative data con-
cerning Fusarium mycotoxins in Bt maize and
non-Bt isogenic maize. Mycotoxin research. 2010
Aug;26(3):141-5.
[60] Pfordt A, Ramos Romero L, Schiwek S, Karlovsky
P, von Tiedemann A. Impact of environmental
conditions and agronomic practices on the preva-
lence of Fusarium species associated with ear-
and stalk rot in maize. Pathogens. 2020 Mar
21;9(3):236.
[61] Pietsch C, Kersten S, Burkhardt-Holm P, Valenta
H, Danicke S. Occurrence of deoxynivalenol and
zearalenone in commercial  sh feed: An initial
study. Toxins. 2013 Jan 16;5(1):184-92.
[62] Polak-Sliwinska M, Paszczyk B. Trichothecenes in
food and feed, relevance to human and animal
health and methods of detection: A systematic
review. Molecules. 2021 Jan 16;26(2):454.
[63] Purnamasari L, Purnomo H. Detection of biolog-
ical and a atoxin B1 contaminants in broiler feed
at the poultry shop Sumbersari District, Jem-
ber. InIOP Conference Series: Earth and Envi-
ronmental Science 2022 Apr 1 (Vol. 1020, No. 1,
p. 012019). IOP Publishing.
[64] Sadiq FA, Yan B, Tian F, Zhao J, Zhang H, Chen
W. Lactic acid bacteria as antifungal and an-
timycotoxigenic agents: a comprehensive review.
Comprehensive Reviews in Food Science and Food
Safety. 2019 Sep;18(5):1403-36.
[65] Salazar-Gonzalez C, Velasquez-Ortiz D, Gomez-
Lopez E. Detection of mycotoxins produced by
Fusarium species in Colombia. Agronoma Colom-
biana. 2020 Aug;38(2):197-204.
[66] Salem IB, Prola A, Boussabbeh M, Guilbert A,
Bacha H, Abid-Esse  S, Lemaire C. Crocin and
Quercetin protect HCT116 and HEK293 cells from
Zearalenone-induced apoptosis by reducing endo-
plasmic reticulum stress. Cell Stress and Chaper-
ones. 2015 Nov 1;20(6):927-38.
[67] Sim~oes D, Carbas B, Soares A, Freitas A, Silva
AS, Brites C, Andrade ED. Assessment of agri-
cultural practices for controlling Fusarium and
mycotoxins contamination on maize grains: Ex-
ploratory study in maize farms. Toxins. 2023 Feb
7;15(2):136.
[68] Sim~oes D, Diogo E, de Andrade E. First report of
Fusarium andiyazi presence in portuguese maize
kernels. Agriculture. 2022 Feb 26;12(3):336.
[69] Sohail M, Bano N, Hamidullah MS, Shah SS,
Shoaib M, Malik M. 34. Quantitative estimation
of a atoxin level in broiler feed utilized in district
Mansehra, Khyber Pakhtunkhwa, Pakistan. Pure
and Applied Biology (PAB). 2020 Apr 6;9(2):1576-
82.
[70] Sohlberg E, Virkajarvi V, Parikka P, Ramo S,
Laitila A, Sarlin T. Taqman qPCR quanti cation
and Fusarium community analysis to evaluate tox-
igenic fungi in cereals. Toxins. 2022 Jan 6;14(1):45.
[71] Sokolovic M, Berendika M, Amsel Zelenika T,
Simpraga B, Krstulovic F. Determination of fu-
monisins in grains and poultry feedstuffs in
Croatia: a 16-year study. Toxins. 2022 Jun
29;14(7):444.
[72] Stanciu O, Banc R, Cozma A, Filip L, Miere D,
Ma~nes J, Loghin F. Occurence of Fusarium myco-
toxins in wheat from Europea review. Acta Uni-
versitatis Cibiniensis. Series E: Food Technology.
2015 Aug 4;19(1):35-60.
[73] Tan DC, Flematti GR, Ghisalberti EL, Siva-
sithamparam K, Chakraborty S, Obanor F, Bar-
betti MJ. Mycotoxins produced by Fusarium
species associated with annual legume pastures
and sheep feed refusal disorders in Western Aus-
tralia. Mycotoxin research. 2011 May;27(2):123-
35.
[74] Tardieu D, Travel A, Metayer JP, Le Bourhis C,
Guerre P. Fumonisin B1, B2 and B3 in muscle and
liver of broiler chickens and Turkey poults fed with
diets containing fusariotoxins at the EU maximum
tolerable level. Toxins. 2019 Oct 11;11(10):590.
[75] Tola M, Kebede B. Occurrence, importance and
control of mycotoxins: A review. Cogent Food
Agriculture. 2016 Dec 31;2(1):1191103.
[76] Valiullin L, Mukhammadiev R, Sevostyanov M,
Demin D, Karimullina I, Mukhammadieva A,
Gumerov V, Sorokina D, Yarullin A, Mukham-
madiev R. Exploring the potential of Bacillus sub-
tilis as an additive for decontamination of feed.
InE3S Web of conferences 2023 (Vol. 462, p.
01021). EDP Sciences.
[77] Vandicke J, De Visschere K, Ameye M, Croubels
S, De Saeger S, Audenaert K, Haesaert G. Multi-
mycotoxin contamination of maize silages in Flan-
ders, Belgium: Monitoring mycotoxin levels from
seed to feed. Toxins. 2021 Mar 11;13(3):202.
[78] Villafana RT, Ramdass AC, Rampersad SN. Se-
lection of Fusarium trichothecene toxin genes for
molecular detection depends on TRI gene cluster
organization and gene function. Toxins. 2019 Jan
14;11(1):36.
[79] Wagacha JM, Steiner U, Dehne HW, Zuehlke S,
Spiteller M, Muthomi J, Oerke EC. Diversity in
mycotoxins and fungal species infecting wheat in
Nakuru District, Kenya. Journal of Phytopathol-
ogy. 2010 Aug;158(78):527-35.
[80] Wang T, Lei H, Zhou L, Tang M, Liu Q, Long F,
Li Q, Su J. Effect of fumonisin B1 on proliferation
and apoptosis of intestinal porcine epithelial cells.
Toxins. 2022 Jul 9;14(7):471.
[81] Placinta CM, D'Mello JF, Macdonald AM. A re-
view of worldwide contamination of cereal grains
and animal feed with Fusarium mycotoxins. An-
imal feed science and technology. 1999 Mar
31;78(1-2):21-37.
[82] Watanabe M, Yonezawa T, Lee KI, Kumagai S,
Sugita-Konishi Y, Goto K, Hara-Kudo Y. Molec-
ular phylogeny of the higher and lower taxonomy
of the Fusarium genus and differences in the evo-
lutionary histories of multiple genes. BMC evolu-
tionary biology. 2011 Nov 3;11(1):322.
[83] Weaver AC, King WD, Verax M, Fox U, Kudupoje
MB, Mathis G, Lumpkins B, Yiannikouris A.
Impact of chronic levels of naturally multi-
contaminated feed with Fusarium mycotoxins on
broiler chickens and evaluation of the mitigation
properties of different titers of yeast cell wall ex-
tract. Toxins. 2020 Oct 1;12(10):636.
[84] Wegulo SN. Factors in uencing deoxynivalenol ac-
cumulation in small grain cereals. Toxins. 2012
Nov 6;4(11):1157-80.
[85] Wing eld LK, Phaichamnan A, Jumnongnit T.
Evaluation of biosecurity and fungal contaminants
in the poultry farms in Songkhla Province, Thai-
land. ScienceAsia. 2021 Aug 1;47(4).
[86] Witaszak N, Stepien  L, Bocianowski J,
Waskiewicz A. Fusarium species and myco-
toxins contaminating veterinary diets for dogs
and cats. Microorganisms. 2019 Jan 21;7(1):26.
[87] Wu F, Cui J, Yang X, Chen B. Effects of zear-
alenone on liver development, antioxidant capac-
ity and in ammatory factors of prepubertal gilts.
Journal of animal physiology and animal nutri-
tion. 2022 Jul;106(4):832-40.
[88] Wu K, Ren C, Gong Y, Gao X, Rajput SA, Qi
D, Wang S. The insensitive mechanism of poultry
to zearalenone: A review. Animal Nutrition. 2021
Sep 1;7(3):587-94.
[89] Wu Y, Wu F, Zhao P, Gao Y, Li M, Luo M,
Zhou Q, Zhou S, Li X, Hong Y, Wu Y. Isola-
tion and Mechanistic Investigation of the Efficient
Zearalenone-Removing Strain Bacillus licheni-
formis YJ25. Toxins. 2025 May 23;17(6):263.
[90] Yang Y, Ashworth AJ, Willett C, Cook K, Upad-
hyay A, Owens PR, Ricke SC, DeBruyn JM,
Moore Jr PA. Review of antibiotic resistance, ecol-
ogy, dissemination, and mitigation in US broiler
poultry systems. Frontiers in Microbiology. 2019
Nov 15;10:2639.
[91] Zhang GL, Feng YL, Song JL, Zhou XS. Zear-
alenone: A mycotoxin with different toxic effect in
domestic and laboratory animals granulosa cells.
Frontiers in genetics. 2018 Dec 18;9:667.
[92] Zhao L, Qi D, Ma Q. Novel Strategies for
the Biodegradation and Detoxi cation of Myco-
toxins in Post-Harvest Grain. Toxins. 2023 Jul
5;15(7):445.